Danforth Avenue (informally also known as the Danforth) and Danforth Road are two historically-related arterial streets in Toronto, Ontario, Canada. Danforth Avenue is an east-west street that begins in Old Toronto at the Prince Edward Viaduct as a physical continuation of Bloor Street and continues for about 6 kilometres (3.7 mi) east through old Toronto, about 350 metres (1,150 ft) of old East York, and a further 5 kilometres (3.1 mi) in Scarborough until it intersects with Kingston Road via a ramped interchange. Danforth Road splits off the Avenue west of Warden Avenue and runs diagonally northeast until south of Lawrence Avenue, where it continues as McCowan Road.

Line 2 Bloor–Danforth of the Toronto subway runs just north of Danforth Avenue from the Don River as far as Main Street station, before gradually veering north as it heads east.